The depository comprises around 40,000 manuscripts of Georgian writers, public figures and artists of the 19th and 20th centuries. The archive documents are diverse, consisting of private and business correspondence, records, scenarios, diaries, poems, plays, printed music, and scores.
The museum contains manuscripts of the following eminent persons: Vazha-Pshavela, Akaki Tsereteli, Galaktion Tabidze, Titsian Tabidze, Ioseb Grishashvili, Ivane Machabeli, Oliver and Marjory Wardrobe, Alexander Sumbatashvili, Kote Meskhi, Kote Kipiania, Nato Gabunia, Elisabed Cherkezishvili, Valerian Gunia, Shalva Dadiani, Dimitri Arakishvili, Kote Marjanishvili, Sandro Akhmeteli, Vano Sarajishvili, Ushangi Chkeidze, Akaki Khorava, Akaki Vasadze, Mikheil Chiaureli, Veriko Anjaparidze, Sergo Zakariadze, Sesilia Takaishvili, Pyotr Tchaikokovsky, Feodor Chaliapin, Dmitri Shostakovich, and Vladimir Ipolitov-Ivanov as well as bibliographical materials about artists, Marjanishvili and Rustaveli Theatres, programmes of Telavi, Kutaisi, Batumi and other regional theatres. There are also valuable materials kept about the history of Georgian and Abkhaz troupes of the Sokhumi Theatre, Georgian and Ossetian troupes of the Tskhinvali Theatre, and Azeri Theatres.
The museum contains documents of the Duruji (Corporation of the Rustaveli Theatre Actors), the Tbilisi Academic State Opera and Ballet Theatre, and programmes of the Tbilisi Drama Society (1893-1903) printed on silk cloth. Besides this, screenplays and scenes of the shooting of Georgian and Russian films are also stored in the museum.